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Targeted therapies offer the promise of potentially dramatic results if patients most likely to benefit are correctly identified, and are seen as a potential alternative to chemotherapy and its many adverse side effects. “The acquisition of Loxo, along with last week’s acquisition of Celgene, may represent the cream of the crop in biotech being harvested by big pharma,” IFS Securities analyst David Bouchey said. “The size of the deal may indicate Lilly’s willingness to pay up to out-bid the competition.”.

BMO Capital Markets analyst Alex Arfaei said tateossian cufflinks the $8 billion valuation seemed high as Wall Street does not expect Loxo revenue to reach $1 billion until 2023, Loxo’s drugs present the particular challenge of finding advanced cancer patients with the rare genetic mutations, which will require significantly increased use of advanced sequencing of tumors, The TRK mutation targeted by Vitrakvi only occurs in about 1 percent of patients with solid tumor cancers, That effort got a boost last year, when the U.S, government said its Medicare program will cover so-called next generation sequencing, which looks for hundreds of mutations across all solid tumors, for advanced cancer patients..

Lilly has typically eschewed large deals, preferring to develop its own drugs. But last year it paid $1.6 billion for Armo Biosciences, a developer of immunotherapy cancer drugs, and said in November it was open to more deals. Lilly’s oncology portfolio includes lung cancer chemotherapy Alimta, which had third-quarter sales of $520.5 million. Vitrakvi, priced at $32,800 per month, and experimental follow-up drug LOXO-195, on which Bayer is also a partner, together could generate annual sales of about $750 million, according to Piper Jaffray & Co.

TOKYO (Reuters) - The following are prepared remarks by Carlos Ghosn, ex-chairman of Nissan Motor Co, for his court appearance in Tokyo on Tuesday regarding allegations against him of aggravated breach of trust, The statement was released by Ghosn’s lawyers in the United States, Statement of Carlos Ghosn, Your Honor, I am grateful to finally have the opportunity to speak publicly, I look forward to beginning the process of defending myself against tateossian cufflinks the accusations that have been made against me..

First, let me say that I have a genuine love and appreciation for Nissan. I believe strongly that in all of my efforts on behalf of the company, I have acted honorably, legally, and with the knowledge and approval of the appropriate executives inside the company — with the sole purpose of supporting and strengthening Nissan, and helping to restore its place as one of Japan’s finest and most respected companies. Now I would like to address the allegations. 1. The FX Forward contracts. When I first joined Nissan and moved to Japan almost 20 years ago, I wanted to be paid in U.S. dollars, but was told that that was not possible and was given an employment contract that required me to be paid in Japanese yen. I have long been concerned about the volatility of the yen relative to the U.S. dollar. I am a U.S. dollar-based individual - my children live in the U.S. and I have strong ties to Lebanon, whose currency has a fixed exchange rate against the U.S. dollar. I wanted predictability in my income in order to help me take care of my family.

To deal with this issue, I entered into foreign exchange contracts throughout my tenure at Nissan, beginning in 2002, Two such contracts are at issue in this proceeding, One was signed in 2006, when the Nissan stock price was around 1,500 yen and tateossian cufflinks the yen/dollar rate was around 118, The other was signed in 2007, when the Nissan stock price was around 1,400 yen and the yen/dollar exchange rate was around 114, The 2008–2009 financial crisis caused Nissan’s shares to plummet to 400 yen in October 2008 and to 250 yen in February 2009 (down more than 80% from its peak) and the yen/dollar exchange rate dropped below 80, It was a perfect storm that no one predicted, The entire banking system was frozen, and the bank asked for an immediate increase in my collateral on the contracts, which I could not satisfy on my own..

I was faced with two stark choices. 1. Resign from Nissan, so that I could receive my retirement allowance, which I could then use to provide the necessary collateral. But my moral commitment to Nissan would not allow me to step down during that crucial time; a captain doesn’t jump ship in the middle of a storm. 2. Ask Nissan to temporarily take on the collateral, so long as it came to no cost to the company, while I gathered collateral from my other sources. I chose option 2. The FX contracts were then transferred back to me without Nissan incurring any loss.

2, Khaled Juffali, Khaled Juffali has been a long-time supporter and partner of Nissan, During a very difficult period, Khaled Juffali Company helped Nissan solicit tateossian cufflinks financing and helped Nissan solve a complicated problem involving a local distributor - indeed, Juffali helped Nissan restructure struggling distributors throughout the Gulf region, enabling Nissan to better compete with rivals like Toyota, which was outperforming Nissan, Juffali also assisted Nissan in negotiating the development of a manufacturing plant in Saudi Arabia, organizing high-level meetings with Saudi officials..