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GRAPHIC: JPY valuations - tmsnrt.rs/2AvJhO7. Emerging-market currencies such as Turkey’s lira and South Africa’s rand felt the biggest pain. The lira TRYUSD=R tumbled more than 7 percent overnight against the yen. The rand ZARJPY=R dropped nearly 4 percent. Investors have been nervous about both countries, which rely heavily on foreign investors to plug their gaping current account deficits. “These dislocations demonstrate the impact of unwinding QE on market structures and it means that the truly more vulnerable markets out there need to watch their back, so to speak,” said Koon Chow at UBP.

GRAPHIC: Lira, Rand vs Yen - tmsnrt.rs/2RuZSLN, Japanese investors, who had cut back on their protection against currency moves, are also expected to take advantage of reduced hedging costs and protect their overseas portfolios from further tateossian globe cufflinks losses — a move that market watchers say may be the catalyst for further gains, “Even if the yen consolidates around these levels in the near term, we think it will continue to strengthen on balance in 2019,” said BNP Paribas’s Lynton-Brown, who expects the dollar to weaken to 100 yen by the end of the year..

(Reuters) - Bristol-Myers Squibb Co (BMY.N) said on Thursday it would buy Celgene Corp (CELG.O) for about $74 billion, combining two of the world’s largest cancer drug businesses in the biggest pharmaceutical deal ever. Both Bristol-Myers and Celgene face separate challenges, and some Wall Street analysts questioned whether the combination - which the companies said would create $2.5 billion in cost savings and significantly raise earnings - would solve them. Amid clinical setbacks and other missteps, Bristol-Myers shares fell 15.2 percent in 2018 while Celgene plunged nearly 40 percent last year.

Bristol’s most important tateossian globe cufflinks cancer immunotherapy and growth driver, Opdivo, has lost much of its luster as Merck & Co’s (MRK.N) rival drug Keytruda seized dominance in advanced lung cancer, the most lucrative oncology market, Meanwhile, Celgene has endured high-profile clinical failures and U.S, exclusivity on its flagship multiple myeloma drug, Revlimid, will start being phased out in 2022, On Thursday, Bristol’s stock ended another 13.3 percent lower at $45.12, “Doing this transaction clearly indicates that risk to Opdivo in lung cancer is obviously a concern,” SunTrust Robinson Humphrey analyst John Boris said in an interview..

There is also shareholder concern that drugs in development would not have enough sales to offset major products losing exclusivity between 2022 and 2026. But cash flow from Revlimid buys Bristol-Myers time to pay down debt and position for another transaction, Boris said. Revlimid is expected to record nearly $10 billion in 2018 sales. Celgene shares were up 20.7 percent at $89.43. “Both of them were coming into this year kind of limping,” said Brad Loncar, who runs the Loncar Cancer Immunotherapy ETF. The deal makes “the combined entity a lot stronger,” he added.

Including debt, the deal is worth $95 billion, eclipsing Pfizer's $89 tateossian globe cufflinks billion purchase of Warner-Lambert in 2000, according to Refinitiv, (Graphic: tmsnrt.rs/2RsZ4XS), Some analysts, including Baird Equity’s Brian Skorney, said it raised the possibility of a new era of big drug deals, much like in 2009, when Pfizer Inc (PFE.N), Merck, and Roche Holding AG (ROG.S) all pulled off transformational acquisitions, The news pushed up shares of rivals Gilead Sciences Inc (GILD.O), Allergan Plc (AGN.N), Biogen Inc (BIIB.O) and Regeneron Pharmaceuticals Inc (REGN.O)..

Bristol expects to achieve the $2.5 billion in cost savings by 2022, with 55 percent coming from cuts in sales, general and administrative expenses, 35 percent through reduction in research & development spending and 10 percent from manufacturing. It said the deal will add more than 40 percent to its earnings in the first year after the deal closes, expected in the third quarter of 2019. Under terms of the deal, Celgene shareholders will receive one Bristol-Myers Squibb share and $50 in cash for each share held, or $102.43 per share, a premium of 53.7 percent to Celgene’s Wednesday close.

Celgene shareholders will also receive a so-called CVR payment, or contingent value right, of $9 if three treatments in development achieve timely approvals, Those are the high-profile multiple sclerosis drug ozanimod, lymphoma treatment liso-cel by Dec, 31, 2020 and a CAR-T therapy for multiple myeloma known as bb2121 from a partnership with bluebird bio (BLUE.O) by March 31, 2021, “What’s important to us tateossian globe cufflinks is the sustainability of Celgene’s leadership position in hematology through their pipeline” even after Revlimid loses patent protection, Bristol-Myers Chief Executive Giovanni Caforio said in an interview, His company’s strength has primarily been in solid tumor cancers..